Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLD1 | Q13393 | 11/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | PLD2 | O14939 | 8/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11033928 | 0.88 | HSD11B1 (0.56) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| SCHEMBL11033800 | 0.86 | HSD11B1 (0.62) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| SCHEMBL11030737 | 0.83 | OPRM1 (0.57) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| SCHEMBL11031792 | 0.83 | OPRM1 (0.55) | PLD1OPRM1OPRK1OPRL1 | |
| SCHEMBL31422674 | 0.82 | OPRM1 (0.71) | PLD1OPRM1PLD2OPRK1OPRL1 | |
| SCHEMBL11032636 | 0.81 | PLD1 (0.64) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| Bromide SCHEMBL11033791 | 0.80 | PLD1 (0.60) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| SCHEMBL10416280 | 0.79 | OPRM1 (0.63) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| SCHEMBL11030553 | 0.79 | HSD11B1 (0.73) | PLD1OPRM1PLD2HSD11B1OPRK1 | |
| Hydrochloric Acid SCHEMBL11033809 | 0.78 | HSD11B1 (0.72) | PLD1OPRM1PLD2HSD11B1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |