Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 2/20 | 0.55 |
| ▸ | CETP | P11597 | 1/20 | 0.54 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MDM4 | O15151 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654049 | 0.79 | TDP1 (0.72) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL9049960 | 0.76 | MAPT (0.64) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL28896841 | 0.74 | TDP1 (1.00) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL11731600 | 0.74 | NPC1 (0.60) | CYP3A4CYP2D6CYP2C9CYP2C19MAPT | |
| SCHEMBL13846441 | 0.73 | TDP1 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL3742208 | 0.72 | SMN1; SMN2 (0.63) | MAPTALDH1A1KMT2AMEN1LMNA | |
| SCHEMBL19712968 | 0.72 | TDP1 (0.62) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL11848833 | 0.72 | ALDH1A1 (1.00) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL24445725 | 0.71 | NPSR1 (0.82) | CYP3A4CYP2D6CYP2C9CYP2C19NPSR1 | |
| SCHEMBL628621 | 0.71 | ALDH1A1 (0.61) | NPSR1MAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0130202-A1 | TETRACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1985-01-09 | — | — | EP | disclosed |
| WO-1984002704-A2 | TETRACYCLIC COMPOUNDS | BEECHAM GROUP PLC (GB) | 1984-07-19 | — | — | WO | disclosed |
| WO-1984002704-A1 | TETRACYCLIC COMPOUNDS | — | 1984-07-19 | — | — | WO | disclosed |