Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | HPGD | P15428 | 6/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9535419 | 0.78 | POLB (0.69) | LMNAALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL22836929 | 0.76 | KDM4E (0.57) | HPGDNPSR1ALDH1A1MAPTNPC1 | |
| SCHEMBL31744573 | 0.76 | EGFR (0.64) | LMNAHPGDNPSR1ALDH1A1MAPT | |
| SCHEMBL9536836 | 0.76 | KCNH3 (0.47) | LMNAHPGDALDH1A1MAPTKMT2A | |
| SCHEMBL9538127 | 0.76 | MAPT (0.60) | LMNANPSR1ALDH1A1MAPTKMT2A | |
| SCHEMBL18415589 | 0.75 | ALDH1A1 (0.64) | LMNAHPGDNPSR1ALDH1A1MAPT | |
| SCHEMBL8348984 | 0.74 | ALDH1A1 (0.51) | HPGDALDH1A1MAPTKMT2ANPC1 | |
| SCHEMBL22852376 | 0.73 | MAPK1 (0.46) | LMNAHPGDNPSR1ALDH1A1MAPT | |
| SCHEMBL31620264 | 0.73 | LMNA (0.54) | LMNAHPGDNPSR1ALDH1A1MAPT | |
| SCHEMBL31620257 | 0.73 | LMNA (0.54) | LMNAHPGDNPSR1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |