Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.60 |
| ▸ | CCKBR | P32239 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.41 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11479334 | 0.86 | NISCH (0.53) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL31150913 | 0.84 | CHRM1 (0.62) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL11476536 | 0.84 | CHRM1 (0.62) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL1199147 | 0.84 | GABRA1 (0.62) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL11037136 | 0.81 | TAAR1 (0.46) | NISCHGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL21133279 | 0.81 | GABRA1 (0.50) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL1198480 | 0.81 | NISCH (0.47) | NISCHCHRM1GABRA1GABRA5GABRA3 | |
| SCHEMBL1199345 | 0.79 | NISCH (0.54) | NISCHGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11684251 | 0.79 | GABRA1 (0.53) | NISCHCCKBRCHRM1GABRA1GABRA5 | |
| SCHEMBL30241878 | 0.77 | NISCH (0.49) | NISCHCHRM1GABRA1GABRA5GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1074216-A | Urea derivative | GLAXO GROUP LTD (GB) | 1993-07-14 | — | — | CN | disclosed |
| CN-1059141-A | BENZODIAZEPINE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO (JP) | 1992-03-04 | — | — | CN | disclosed |
| EP-0135770-A2 | Imidazobenzodiazepine derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-04-03 | — | — | EP | disclosed |