Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11467997 | 0.86 | GABRA1 (0.61) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL29611554 | 0.86 | GABRA1 (0.61) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL28788718 | 0.82 | NISCH (0.45) | ADRA2BADRA2CLMNAMAOAMAOB | |
| SCHEMBL11035945 | 0.81 | NISCH (0.60) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL1199345 | 0.81 | NISCH (0.54) | TAAR1ADRA2BADRA2CLMNAMAOA | |
| SCHEMBL4564319 | 0.78 | GABRP (0.68) | ADRA2BADRA2CLMNAGABRA1GABRA5 | |
| SCHEMBL29575850 | 0.78 | GABRP (0.68) | ADRA2BADRA2CLMNAGABRA1GABRA5 | |
| SCHEMBL27817591 | 0.77 | GABRA1 (0.44) | TAAR1ADRA2BADRA2CLMNAKMT2A | |
| SCHEMBL2851128 | 0.77 | NISCH (0.56) | ADRA2BADRA2CLMNAMAOAMAOB | |
| SCHEMBL2949149 | 0.77 | NISCH (0.62) | MAOAMAOBNISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0135770-A2 | Imidazobenzodiazepine derivatives, process for their preparation and medicaments containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1985-04-03 | — | — | EP | disclosed |