Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 6/20 | 0.54 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.53 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.53 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.53 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.48 |
| ▸ | ADRA2B | P18089 | 7/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 7/20 | 0.48 |
| ▸ | MAOA | P21397 | 5/20 | 0.48 |
| ▸ | MAOB | P27338 | 5/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13585229 | 0.81 | NOS2 (0.56) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11460470 | 0.81 | CHRM1 (0.59) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL5598008 | 0.81 | NISCH (0.44) | NISCHADRA2AADRA2BADRA2C | |
| SCHEMBL1199602 | 0.81 | CHRM1 (0.59) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL29414926 | 0.81 | CHRM1 (0.59) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL12876624 | 0.81 | CHRM1 (0.59) | NISCHADRA2AADRA2BADRA2CMAOA | |
| SCHEMBL11037136 | 0.81 | TAAR1 (0.46) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11870795 | 0.79 | NISCH (0.51) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11870789 | 0.79 | NISCH (0.51) | NISCHGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL11035945 | 0.79 | NISCH (0.60) | NISCHGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0096320-B1 | USE OF 5-PHENYL-1,4-BENZODIAZEPINES FOR THE MANUFACTURE OF ANALGESIC PHARMACEUTICAL COMPOSITIONS | Kali-Chemie Pharma GmbH (DE) | 1986-04-30 | — | — | EP | claimed |
| US-4482548-A | Analgesic pharmaceutical compositions containing 5-phenyl-1,4-benzo diazepine compounds and a method of using same | KALI-CHEMIE PHARMA GMBH (GB) | 1984-11-13 | — | — | US | claimed |
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| EP-1812112-B1 | Benzodiazepine derivatives as ROCK kinases inhibitors | GLAXOSMITHKLINE LLC (US) | 2011-04-27 | — | — | EP | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-7888503-B2 | Benzodiazepine derivatives that inhibit rock | GLAXOSMITHKLINE LLC (US) | 2011-02-15 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| US-20090143366-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC | 2009-06-04 | — | — | US | disclosed |
| EP-1812112-A2 | CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2007-08-01 | — | — | EP | disclosed |
| WO-1994006291-A1 | SOLID PHASE AND COMBINATORIAL SYNTHESIS OF COMPOUNDS ON A SOLID SUPPORT | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1994-03-31 | — | — | WO | disclosed |
| CN-1074216-A | Urea derivative | GLAXO GROUP LTD (GB) | 1993-07-14 | — | — | CN | disclosed |
| CN-1063103-A | BENZODIAZEPINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 1992-07-29 | — | — | CN | disclosed |
| EP-0387618-A1 | 1,7-Fused 1H-indole-2-carboxylic N-(1,4-benzodiazepin-3-yl)-amides | Kali-Chemie Pharma GmbH (DE) | 1990-09-19 | — | — | EP | disclosed |
| US-4505908-A | TRANQUILIZERS | KALI-CHEMIE PHARMA GMBH (DE) | 1985-03-19 | — | — | US | disclosed |
| US-4482548-A | Analgesic pharmaceutical compositions containing 5-phenyl-1,4-benzo diazepine compounds and a method of using same | KALI-CHEMIE PHARMA GMBH (GB) | 1984-11-13 | — | — | US | disclosed |
| EP-0096320-A1 | Use of 5-phenyl-1,4-benzodiazepines for the manufacture of analgesic pharmaceutical compositions | Kali-Chemie Pharma GmbH (DE) | 1983-12-21 | — | — | EP | disclosed |
| US-4044003-A | Process for preparing 1,4-benzodiazepines | SUMITOMO CHEMICAL COMPANY, LIMITED (JA) | 1977-08-23 | — | — | US | disclosed |
| US-3984545-A | 3,4-DIHYDROXY-PHENYL-1-ANALINE WITH BENZODIAZEPINES | THE UPJOHN COMPANY (US) | 1976-10-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143366-A1 | CHEMICAL COMPOUNDS | ROCK2, ROCK1, ABL1 | NISCH 864/4885GABRA1 755/4885GABRG2 985/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.