Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | AR | P10275 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595917 | 0.82 | LMNA (0.60) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8619179 | 0.80 | KCNH3 (0.43) | ALDH1A1HPGDMEN1KMT2ATP53 | |
| SCHEMBL665518 | 0.79 | APP (0.69) | NPC1RAB9ASMN1; SMN2ALDH1A1AR | |
| Hydrochloric Acid SCHEMBL17890756 | 0.77 | APP (0.67) | NPC1RAB9ASMN1; SMN2ALDH1A1AR | |
| SCHEMBL11601970 | 0.77 | LMNA (0.69) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL6852891 | 0.77 | GAA (0.50) | NPC1RAB9ASMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL28029525 | 0.76 | MEN1 (0.63) | ALDH1A1ARMEN1KMT2ALMNA | |
| SCHEMBL4407617 | 0.76 | ENPP2 (0.62) | RAB9ASMN1; SMN2MEN1KMT2ALMNA | |
| SCHEMBL2545271 | 0.75 | KCNH3 (0.40) | RAB9ASMN1; SMN2ALDH1A1HPGDMEN1 | |
| SCHEMBL10584523 | 0.75 | KCNH3 (0.40) | RAB9ASMN1; SMN2ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0052072-B1 | 3-AMINOPROPOXYPHENYL DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SANDOZ AG (CH) | 1985-02-20 | — | — | EP | disclosed |