Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10952273 | 0.91 | KMT2A (0.42) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10958963 | 0.87 | KMT2A (0.39) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10960512 | 0.85 | AKR1A1 (0.47) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL11045582 | 0.85 | APAF1 (0.49) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10802626 | 0.84 | APAF1 (0.48) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10957677 | 0.83 | UCHL1 (0.42) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10957718 | 0.83 | KMT2A (0.38) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL10955668 | 0.83 | AKR1B1 (0.47) | APAF1KMT2AALDH1A1TP53CYP1A2 | |
| SCHEMBL11048622 | 0.83 | SCN9A (0.41) | AKR1A1AKR1B1PTPN1 | |
| SCHEMBL11003981 | 0.80 | GFER (0.43) | APAF1KMT2AALDH1A1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0066378-B1 | PHARMACEUTICAL SPIRO-HYDANTOIN DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1985-01-02 | — | — | EP | disclosed |
| US-4490381-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS, ALSO ALDOSE REDUCTASE INHIBIIOTRS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-12-25 | — | — | US | disclosed |
| US-4386100-A | COMPLICATIONS OF DIABETES OR GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-05-31 | — | — | US | disclosed |
| EP-0066378-A1 | Pharmaceutical spiro-hydantoin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-08 | — | — | EP | disclosed |
| EP-0028906-A1 | 1'-Substituted-spiro(imidazolidine-4,3'-indoline)-2,2',5-triones, processes for their manufacture and pharmaceutical compositions thereof | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-05-20 | — | — | EP | disclosed |