Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 2/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | CMA1 | P23946 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10960512 | 0.86 | AKR1A1 (0.47) | PTGDR2AKR1B1AKR1A1 | |
| SCHEMBL10952273 | 0.85 | KMT2A (0.42) | AKR1B1AKR1A1PTPN1 | |
| SCHEMBL10957677 | 0.84 | UCHL1 (0.42) | AKR1B1AKR1A1 | |
| SCHEMBL10955668 | 0.84 | AKR1B1 (0.47) | PTGDR2AKR1B1AKR1A1 | |
| SCHEMBL10957718 | 0.84 | KMT2A (0.38) | PTGDR2CCR2AKR1B1AKR1A1PTPN1 | |
| SCHEMBL11037537 | 0.83 | APAF1 (0.44) | AKR1B1AKR1A1PTPN1 | |
| SCHEMBL10802626 | 0.83 | APAF1 (0.48) | SCN9AAKR1B1AKR1A1 | |
| SCHEMBL10958963 | 0.81 | KMT2A (0.39) | PTGDR2CCR2AKR1B1AKR1A1PTPN1 | |
| SCHEMBL11003981 | 0.81 | GFER (0.43) | CCR2AKR1B1 | |
| SCHEMBL11045582 | 0.80 | APAF1 (0.49) | SCN9ACCR2AKR1B1AKR1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4490381-A | HYPOGLYCEMIC AND ANTIDIABETIC AGENTS, ALSO ALDOSE REDUCTASE INHIBIIOTRS | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-12-25 | — | — | US | disclosed |
| EP-0028906-B1 | 1'-SUBSTITUTED-SPIRO(IMIDAZOLIDINE-4,3'-INDOLINE)-2,2',5-TRIONES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS THEREOF | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1984-10-03 | — | — | EP | disclosed |
| US-4386100-A | COMPLICATIONS OF DIABETES OR GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-05-31 | — | — | US | disclosed |
| EP-0066378-A1 | Pharmaceutical spiro-hydantoin derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1982-12-08 | — | — | EP | disclosed |