SCHEMBL11039664

SCHEMBL11039664

COc1cccc(C=O)c1OC=O

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRC P12931 1/20 0.61
TLR2 O60603 1/20 0.58
ERN1 O75460 1/20 0.58
TLR1 Q15399 1/20 0.58
TLR6 Q9Y2C9 1/20 0.58
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
LMNA P02545 3/20 0.50
ALDH1A1 P00352 3/20 0.50
CYP1A2 P05177 3/20 0.50
CYP2C9 P11712 1/20 0.50
CYP2C19 P33261 1/20 0.50
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
NFE2L2 Q16236 5/20 0.47
PRMT1 Q99873 1/20 0.45
KDM4E B2RXH2 2/20 0.43
HPGD P15428 1/20 0.43
GAA P10253 1/20 0.43
KMT2A Q03164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10434914 0.89 SRC (0.65) SRCTLR2ERN1TLR1TLR6
O-Veratraldehyde SCHEMBL319070 0.86 SRC (0.67) SRCTLR2ERN1TLR1TLR6
O-Veratraldehyde SCHEMBL28289918 0.86 SRC (0.67) SRCTLR2ERN1TLR1TLR6
O-Veratraldehyde SCHEMBL29923149 0.86 SRC (0.67) SRCTLR2ERN1TLR1TLR6
SCHEMBL2094352 0.86 SMN1; SMN2 (0.48) SRCTLR2ERN1TLR1TLR6
SCHEMBL8577246 0.84 SRC (0.56) SRCTLR2ERN1TLR1TLR6
SCHEMBL12904379 0.81 SRC (0.61) SRCTLR2ERN1TLR1TLR6
SCHEMBL28023292 0.81 SRC (0.61) SRCTLR2ERN1TLR1TLR6
SCHEMBL8007602 0.81 SRC (0.61) SRCTLR2ERN1TLR1TLR6
O-Veratraldehyde SCHEMBL8706125 0.80 SRC (0.59) SRCTLR2ERN1TLR1TLR6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0044260-B1 PROCESS FOR THE PREPARATION OF POLYPHENOLS OPTIONALLY SUBSTITUTED BY AN ALDEHYDE GROUP RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-04-11 EP claimed
US-4435601-A OXIDATION WITH HYDROGEN PEROXIDE IN ALKALI OR ALKALINE METAL BASE RHONE-POULENC INDUSTRIES (FR) 1984-03-06 US claimed
EP-0044260-A2 Process for the preparation of polyphenols optionally substituted by an aldehyde group RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-01-20 EP claimed
US-10059731-B2 Process for depolymerization of lignin by laccases INSTITUT POLYTECHNIQUE DE BORDEAUX (FR) 2018-08-28 US disclosed
US-20160376300-A1 PROCESS FOR DEPOLYMERIZATION OF LIGNIN BY LACCASES INSTITUT OF POLYTECHNIQUE DE BORDEAUX (FR) 2016-12-29 US disclosed
CN-105899728-A Method for depolymerizing lignin by laccase 波尔多聚合技术研究所 2016-08-24 CN disclosed
EP-0044260-B1 PROCESS FOR THE PREPARATION OF POLYPHENOLS OPTIONALLY SUBSTITUTED BY AN ALDEHYDE GROUP RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1984-04-11 EP disclosed
US-4435601-A OXIDATION WITH HYDROGEN PEROXIDE IN ALKALI OR ALKALINE METAL BASE RHONE-POULENC INDUSTRIES (FR) 1984-03-06 US disclosed
US-4351962-A Process for the preparation of hydroxy benzene carboxaldehydes RHONE POULENC INC. (US) 1982-09-28 US disclosed
EP-0044260-A2 Process for the preparation of polyphenols optionally substituted by an aldehyde group RHONE-POULENC SPECIALITES CHIMIQUES (FR) 1982-01-20 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160376300-A1 PROCESS FOR DEPOLYMERIZATION OF LIGNIN BY LACCASES LOX, LPO, LCT SRC 1408/4885TLR2 1525/4885ERN1 2843/4885
US-10059731-B2 Process for depolymerization of lignin by laccases LOX, LPO, LCT SRC 1408/4885TLR2 1525/4885ERN1 2843/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.