Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.48 |
| ▸ | YAP1 | P46937 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1103969 | 0.89 | GPR119 (0.44) | GPR119GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL1103944 | 0.89 | GRIN2B (0.45) | GPR119YAP1GRIN2BCYP3A4CYP2D6 | |
| SCHEMBL1103976 | 0.86 | GRIN2B (0.41) | GPR119GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12198287 | 0.85 | GPR119 (0.44) | GPR119PRMT5 | |
| SCHEMBL14006541 | 0.84 | YAP1 (0.48) | YAP1GRIN2BSLC2A1PRMT5 | |
| SCHEMBL11957012 | 0.80 | GPR119 (0.57) | GPR119 | |
| SCHEMBL4694452 | 0.78 | HRH3 (0.50) | GPR119YAP1 | |
| SCHEMBL1103945 | 0.78 | GRIN2B (0.43) | GRIN2BCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL12813454 | 0.78 | YAP1 (0.66) | GPR119YAP1SLC2A1PRMT5 | |
| SCHEMBL6190651 | 0.78 | F10 (0.56) | YAP1SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8153635-B2 | Compounds and compositions as modulators of GPR119 activity | IRM LLC (BM) | 2012-04-10 | — | — | US | disclosed |
| US-20090270409-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-10-29 | — | — | US | disclosed |
| WO-2009038974-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270409-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | GPR119, GPR65, GPR39 | GPR119 1/4885YAP1 2821/4885GRIN2B 275/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.