Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.64 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | PPARG | P37231 | 9/20 | 0.40 |
| ▸ | PPARD | Q03181 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | ADK | P55263 | 2/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038271 | 0.84 | CA2 (0.45) | CA2SLC6A2SLC6A4SLC6A3GSK3B | |
| SCHEMBL10756742 | 0.81 | CA2 (0.51) | CA2PPARGPPARDPPARA | |
| Pemoline Dione SCHEMBL7864463 | 0.78 | CA2 (1.00) | CA2SLC6A3PPARGPPARDPPARA | |
| Pemoline Dione SCHEMBL11265294 | 0.77 | CA2 (0.96) | CA2SLC6A3PPARGPPARDPPARA | |
| SCHEMBL11038399 | 0.75 | CA2 (0.66) | CA2PPARGPPARDPPARAKCNH2 | |
| SCHEMBL11043058 | 0.75 | CA2 (0.66) | CA2SLC6A2SLC6A4SLC6A3PPARG | |
| SCHEMBL11040723 | 0.73 | CA2 (0.64) | CA2PPARGPPARDPPARAKDM4E | |
| SCHEMBL13581327 | 0.73 | CA2 (0.64) | CA2PPARGPPARDPPARA | |
| SCHEMBL11686374 | 0.72 | SLC6A4 (0.40) | SLC6A2SLC6A4SLC6A3MMP13CYP2D6 | |
| SCHEMBL898510 | 0.72 | CA2 (0.67) | CA2PPARGPPARDPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |