Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.38 |
| ▸ | ADK | P55263 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11040411 | 0.84 | CA2 (0.64) | CA2SLC6A2SLC6A4SLC6A3GSK3B | |
| SCHEMBL8181404 | 0.80 | CA2 (0.67) | CA2SLC6A3GSK3BMEN1KMT2A | |
| SCHEMBL8181750 | 0.70 | MAPT (0.45) | SLC6A2SLC6A4SLC6A3MEN1KMT2A | |
| SCHEMBL6942093 | 0.68 | ALDH1A1 (0.64) | CA2SLC6A2GSK3BADKMEN1 | |
| SCHEMBL2829814 | 0.66 | TDP1 (0.54) | SLC6A2SLC6A4SLC6A3MMP13MEN1 | |
| SCHEMBL31366855 | 0.66 | CA2 (0.66) | CA2SLC6A2SLC6A4SLC6A3MMP13 | |
| SCHEMBL10756742 | 0.66 | CA2 (0.51) | CA2 | |
| SCHEMBL11686370 | 0.66 | SLC6A4 (0.39) | SLC6A2SLC6A4SLC6A3GSK3BADK | |
| SCHEMBL30658773 | 0.65 | POLB (0.67) | SLC6A2SLC6A4SLC6A3GSK3BADK | |
| SCHEMBL18025750 | 0.65 | PDE4A (0.51) | SLC6A2SLC6A4SLC6A3GSK3BMMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4448971-A | Hypoglycemic 5-phenyl-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1984-05-15 | — | — | US | disclosed |
| US-4407811-A | Hypoglycemic 5-substituted oxazolidine-2,4-diones | PFIZER INC. (US) | 1983-10-04 | — | — | US | disclosed |
| US-4399296-A | TRIMETHYLSILYL CYANOHYDRIN INTERMEDIATES | PFIZER INC. (US) | 1983-08-16 | — | — | US | disclosed |
| US-4367234-A | HYPOGLYCEMIC AGENTS | PFIZER INC. (US) | 1983-01-04 | — | — | US | disclosed |