Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 6/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | PGR | P06401 | 3/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | SHBG | P04278 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 4/20 | 0.45 |
| ▸ | FNTB | P49356 | 4/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11039057 | 1.00 | NR3C1 (0.55) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL4738 | 0.84 | NR3C1 (0.76) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL11123749 | 0.82 | SHBG (0.56) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL11039814 | 0.82 | SHBG (0.56) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL11038397 | 0.80 | HIF1A (0.71) | NR3C1HIF1APGRSHBGFNTA | |
| SCHEMBL11039918 | 0.80 | HIF1A (0.71) | NR3C1HIF1APGRSHBGFNTA | |
| SCHEMBL4546 | 0.76 | NR3C1 (0.74) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL143178 | 0.76 | NR3C1 (0.74) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL722408 | 0.76 | SHBG (0.64) | NR3C1HIF1APGRHRH1SHBG | |
| SCHEMBL11041672 | 0.73 | PGR (0.71) | NR3C1HIF1APGRCYP2C19AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0123485-A1 | Colon-specific prodrug, the preparation and uses thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1984-10-31 | — | — | EP | disclosed |
| WO-1984004041-A1 | COLON-SPECIFIC DRUG DELIVERY SYSTEM | UNIV CALIFORNIA (US) | 1984-10-25 | — | — | WO | disclosed |