Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | PARP1 | P09874 | 4/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.41 |
| ▸ | PARP14 | Q460N5 | 3/20 | 0.41 |
| ▸ | PARP15 | Q460N3 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.41 |
| ▸ | RELA | Q04206 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8689035 | 0.85 | PARP1 (0.55) | MEN1KMT2APARP1PARP10PARP14 | |
| SCHEMBL171243 | 0.83 | RAB9A (0.55) | ALDH1A1MEN1KMT2ANPC1PKM | |
| SCHEMBL3901564 | 0.81 | KMT2A (0.60) | ALDH1A1TDP1MEN1KMT2ANPC1 | |
| SCHEMBL2445253 | 0.79 | RAB9A (0.59) | ALDH1A1MEN1KMT2ANPC1MAPT | |
| SCHEMBL7410095 | 0.78 | PRSS1 (0.49) | ALDH1A1 | |
| SCHEMBL21634636 | 0.77 | GAA (0.48) | ALDH1A1TDP1MEN1KMT2APARP1 | |
| SCHEMBL7113447 | 0.77 | GSK3B (0.53) | ALDH1A1MEN1KMT2ANPC1MAPT | |
| SCHEMBL12129057 | 0.77 | ALDH1A1 (0.67) | ALDH1A1MEN1KMT2ANPC1MAPT | |
| SCHEMBL14418364 | 0.75 | NPSR1 (0.54) | ALDH1A1NPC1MAPTSMN1; SMN2TP53 | |
| SCHEMBL11363889 | 0.75 | KMT2A (0.41) | ALDH1A1MEN1KMT2APARP1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |