Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | CCR1 | P32246 | 3/20 | 0.47 |
| ▸ | CCR5 | P51681 | 3/20 | 0.47 |
| ▸ | CCR8 | P51685 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MMP2 | P08253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.47 |
| ▸ | THPO | P40225 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3820324 | 0.80 | LMNA (0.43) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL1900105 | 0.80 | LMNA (0.67) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL18839312 | 0.79 | LMNA (0.38) | LMNAKDM4EHSP90AA1HTTCCNA2 | |
| SCHEMBL6995995 | 0.76 | LMNA (0.78) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL600668 | 0.73 | CCR1 (0.60) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL27885494 | 0.73 | LMNA (0.96) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL7368978 | 0.73 | LMNA (0.61) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| Anthracene SCHEMBL28175852 | 0.73 | LMNA (0.85) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| Benzonaphthyridine SCHEMBL29137083 | 0.72 | CCR1 (0.64) | LMNAKDM4EMAPTSMN1; SMN2CCR1 | |
| SCHEMBL10923588 | 0.72 | LMNA (0.78) | LMNAKDM4EMAPTSMN1; SMN2CCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0045521-B1 | PYRAZOLOBENZAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-06-27 | — | — | EP | claimed |
| EP-0045521-A1 | Pyrazolobenzazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | claimed |
| CN-111479813-B | Triazolobenzazepines as vasopressin V1A receptor antagonists | 吉瑞工厂 | 2023-03-21 | — | — | CN | disclosed |
| CN-111479813-A | Triazolobenzazepines as vasopressin V1A receptor antagonists | 吉瑞工厂 | 2020-07-31 | — | — | CN | disclosed |
| US-4460781-A | PREPARATION OF PYRAZOLOBENZAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1984-07-17 | — | — | US | disclosed |
| US-4460781-A | PREPARATION OF PYRAZOLOBENZAZEPINES | HOFFMANN-LA ROCHE INC. (US) | 1984-07-17 | — | — | US | disclosed |
| EP-0045521-B1 | PYRAZOLOBENZAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-06-27 | — | — | EP | disclosed |
| EP-0045521-B1 | PYRAZOLOBENZAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-06-27 | — | — | EP | disclosed |
| US-4379765-A | SEDATIVES, ANXIETY | HOFFMANN-LA ROCHE INC. (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379765-A | SEDATIVES, ANXIETY | HOFFMANN-LA ROCHE INC. (US) | 1983-04-12 | — | — | US | disclosed |
| US-4379765-A | SEDATIVES, ANXIETY | HOFFMANN-LA ROCHE INC. (US) | 1983-04-12 | — | — | US | disclosed |
| EP-0045521-A1 | Pyrazolobenzazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |
| EP-0045521-A1 | Pyrazolobenzazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |
| EP-0045521-A1 | Pyrazolobenzazepines, process for their preparation and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |
| US-4028381-A | ANTIANXIETY AND ANTIDEPRESSANT AGENTS | CIBA-GEIGY CORPORATION (US) | 1977-06-07 | — | — | US | disclosed |
| US-4022801-A | ANTIANXIETY AND ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1977-05-10 | — | — | US | disclosed |
| US-3947585-A | ANTIANXIETY, ANTIDEPRESSANTS | CIBA-GEIGY CORPORATION (US) | 1976-03-30 | — | — | US | disclosed |