Benzonaphthyridine

Benzonaphthyridine

SCHEMBL29137083

c1ccc2c(c1)nnc1ccccc12.c1cnc2c(c1)ccc1cccnc12

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR1 P32246 5/20 0.64
CCR8 P51685 5/20 0.64
KDM4E B2RXH2 4/20 0.64
LMNA P02545 3/20 0.64
CCR5 P51681 3/20 0.64
MAPT P10636 3/20 0.64
CYP3A4 P08684 2/20 0.64
MMP2 P08253 2/20 0.64
TSHR P16473 2/20 0.64
HSP90AA1 P07900 2/20 0.64
SMN1; SMN2 Q16637 2/20 0.64
TDP1 Q9NUW8 2/20 0.64
GMNN O75496 1/20 0.64
TP53 P04637 1/20 0.64
CYP2D6 P10635 1/20 0.64
MMP9 P14780 1/20 0.64
ALOX15 P16050 1/20 0.64
NFKB1 P19838 1/20 0.64
MMP8 P22894 1/20 0.64
THPO P40225 1/20 0.64

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phenanthrene SCHEMBL16685315 0.83 CCR1 (0.76) CCR1CCR8KDM4ELMNACCR5
SCHEMBL30895368 0.81 GPR3 (0.56) CCR1CCR8KDM4ELMNACCR5
SCHEMBL11199602 0.81 GPR3 (0.56) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL5192184 0.81 LMNA (0.73) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL27546799 0.81 ALDH1A1 (0.77) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL29013283 0.80 CCR1 (0.89) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL29367277 0.80 CCR1 (1.00) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL29354015 0.80 CCR1 (1.00) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL8845760 0.80 CCR1 (1.00) CCR1CCR8KDM4ELMNACCR5
Phenanthroline SCHEMBL8312 0.80 CCR1 (1.00) CCR1CCR8KDM4ELMNACCR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115141138-B Method for constructing fluoride by decarboxylation of alkyl carboxylic acid 中山大学 2023-11-28 CN disclosed