Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | PPM1B | O75688 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | LGMN | Q99538 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL294716 | 0.83 | LMNA (0.43) | LMNAALOX15MGAMGAASI | |
| SCHEMBL3237652 | 0.80 | MAPT (0.37) | CYP1A2LMNAMAPTALDH1A1PPM1B | |
| SCHEMBL16409442 | 0.79 | LMNA (0.41) | LMNAALOX15GAAMAPTCYP3A4 | |
| SCHEMBL1061265 | 0.79 | SLC6A4 (0.42) | CYP1A2ALOX15MAPTPPM1BPTPN1 | |
| SCHEMBL12846027 | 0.77 | GAA (0.42) | LMNAGAAMAPTCYP3A4CYP2D6 | |
| SCHEMBL3691417 | 0.77 | ALDH1A1 (0.47) | LMNAALOX15GAAMAPTCYP3A4 | |
| SCHEMBL6574520 | 0.77 | MAPT (0.40) | CYP1A2LMNAALOX15GAAMAPT | |
| SCHEMBL24766447 | 0.76 | LMNA (0.39) | LMNAGAAMAPTCYP3A4CYP2D6 | |
| SCHEMBL13449196 | 0.76 | LMNA (0.39) | LMNAALOX15GAAMAPTCYP3A4 | |
| SCHEMBL24766727 | 0.76 | LMNA (0.39) | LMNAGAAMAPTCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0068999-B1 | DERIVATIVES OF 1-ARYL-2-AMINOMETHYL-CYCLOPROPANE-CARBOXAMIDES (Z), THEIR PREPARATION AND THEIR USE AS MEDICINES IN THE TREATMENT OF DISORDERS OF THE CENTRAL NERVOUS SYSTEM | PIERRE FABRE S.A. (FR) | 1985-05-22 | — | — | EP | disclosed |
| EP-0068999-A1 | Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system | PIERRE FABRE S.A. (FR) | 1983-01-05 | — | — | EP | disclosed |