Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.31 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.31 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.31 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.31 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.31 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL147493 | 0.97 | TSHR (0.37) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| Hydrochloric Acid SCHEMBL7722967 | 0.94 | OPRK1 (0.36) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL11494978 | 0.92 | KDM4E (0.34) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL170617 | 0.92 | OPRM1 (0.38) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| Hydrochloric Acid SCHEMBL1234433 | 0.89 | OPRM1 (0.40) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| Trolamine SCHEMBL9856574 | 0.89 | TSHR (0.35) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL31711370 | 0.89 | OPRM1 (0.37) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| Ammonia Solution, Strong SCHEMBL4662387 | 0.89 | OPRM1 (0.37) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL11493587 | 0.87 | KDM4E (0.33) | KDM4EKMT2ASMN1; SMN2MEN1TSHR | |
| SCHEMBL20835283 | 0.86 | OPRM1 (0.36) | KDM4EKMT2ASMN1; SMN2MEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4483959-A | Organic pigments | HERCULES INCORPORATED (US) | 1984-11-20 | — | — | US | disclosed |
| US-4469555-A | OPACIFYING AGENTS FOR PAPER | HERCULES INCORPORATED (US) | 1984-09-04 | — | — | US | disclosed |
| US-4456724-A | GRAFT POLYMERIZING UNSATURATED MONOMER ONTO WATER SOLUBLE CATIONIC PREPOLYMER | HERCULES INCORPORATED (US) | 1984-06-26 | — | — | US | disclosed |
| US-4434267-A | PAPER FILLERS AND COATINGS | HERCULES INCORPORATED (US) | 1984-02-28 | — | — | US | disclosed |
| US-4426483-A | CROSSLINKED GRAFT POLYMERS OF UNSATURATED MONOMERS | HERCULES INCORPORATED (US) | 1984-01-17 | — | — | US | disclosed |
| US-4414353-A | GRAFT POLYMERS AS FILLERS FOR PAPER | HERCULES INCORPORATED (US) | 1983-11-08 | — | — | US | disclosed |
| US-4404310-A | GRAFT POLYMERS OF UNSATURATED COMPOUND ONTO WATER SOLUBLE CATIONIC POLYMERS | HERCULES INCORPORATED (US) | 1983-09-13 | — | — | US | disclosed |
| US-4403062-A | GRAFT POLYMERS OF UNSATURATED COMPOUND ONTO WATER SOLUBLE CATIONIC POLYMERS | HERCULES INCORPORATED (US) | 1983-09-06 | — | — | US | disclosed |
| US-4403063-A | GRAFT POLYMERS, CATIONIC POLYMERS | HERCULES INCORPORATED (US) | 1983-09-06 | — | — | US | disclosed |
| US-4369292-A | LIGHTWEIGHT FILLERS FOR PAPER; PARTICLES FROM FTHE GRAFT COPOLYMERJIZATION OF AN UNSATURATED MONOMER AND A CATIONIC POLYMER | HERCULES INCORPORATED (US) | 1983-01-18 | — | — | US | disclosed |
| US-4235982-A | POLYMERIC FILLERS FOR PAPER | HERCULES, INCORPORATED (US) | 1980-11-25 | — | — | US | disclosed |
| US-4156628-A | TREATMENT WITH CATIONIC AND ANIONIC WATER-SOLUBLE, NITROGEN-CONTAINING POLYMERS | HERCULES INCORPORATED (US) | 1979-05-29 | — | — | US | disclosed |
| US-4154646-A | TREATMENT WITH AQUEOUS MIXTURE OF CATIONIC AND ANIONIC WATER-SOLUBLE NITROGEN-CONTAINING POLYMERS | HERCULES INCORPORATED (US) | 1979-05-15 | — | — | US | disclosed |
| US-4109053-A | SIZING PAPER WITH STABLE DISPERSIONS OF HYDROCARBON RESINS | HERCULES INCORPORATED (US) | 1978-08-22 | — | — | US | disclosed |
| US-4017431-A | Aqueous dispersions of wax blends and a water-soluble cationic resin and paper sized therewith | HERCULES INCORPORATED (US) | 1977-04-12 | — | — | US | disclosed |
| US-3966684-A | RETENTION AIDS FOR PAPER FILLERS | HERCULES INCORPORATED (US) | 1976-06-29 | — | — | US | disclosed |
| US-3966654-A | CATIONIC AMINOPOLYAMIDE-EPICHLOROHYDRIN RESIN | HERCULES INCORPORATED (US) | 1976-06-29 | — | — | US | disclosed |
| US-3966694-A | RETENTION AIDS FOR PAPER FILLERS | HERCULES INCORPORATED (US) | 1976-06-29 | — | — | US | disclosed |
| US-3951921-A | PAPER FILLERS | HERCULES INCORPORATED (US) | 1976-04-20 | — | — | US | disclosed |
| US-3941736-A | Stable aqueous dispersions of hydrocarbon resins and water soluble polyaminopolyamide-epichlorohydrin resin as dispersing agent | HERCULES INCORPORATED (US) | 1976-03-02 | — | — | US | disclosed |