Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Succinamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BLM | P54132 | 5/20 | 0.41 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GMNN | O75496 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylenediamine SCHEMBL3266185 | 0.89 | NFKB1 (0.50) | BLMLMNAALOX15ALDH1A1CYP1A2 | |
| Succinamide SCHEMBL36057 | 0.88 | — | — | |
| Succinamide SCHEMBL28157588 | 0.88 | LMNA (0.50) | BLMLMNAALOX15ALDH1A1CYP1A2 | |
| Ethylenediamine SCHEMBL27614928 | 0.87 | LMNA (0.53) | BLMLMNAALOX15ALDH1A1CYP1A2 | |
| SCHEMBL82768 | 0.85 | — | — | |
| Succinamide SCHEMBL29269227 | 0.84 | — | — | |
| Succinamide SCHEMBL28650219 | 0.84 | — | — | |
| Succinamide SCHEMBL1647263 | 0.84 | LMNA (0.47) | BLMLMNAALOX15ALDH1A1CYP1A2 | |
| Succinamide SCHEMBL21530847 | 0.84 | LMNA (0.47) | BLMLMNAALOX15ALDH1A1CYP1A2 | |
| Succinamide SCHEMBL28836984 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4480041-A | IMMUNOASSAY | COLLABORATIVE RESEARCH, INC. (US) | 1984-10-30 | — | — | US | disclosed |