Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043872 | 1.00 | APP (0.42) | APPLMNAMEN1THRBBLM | |
| SCHEMBL3811810 | 0.84 | LMNA (0.41) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL14485246 | 0.78 | APP (0.42) | APPNFE2L2 | |
| SCHEMBL31667122 | 0.78 | APP (0.42) | APPNFE2L2 | |
| SCHEMBL1999676 | 0.78 | APP (0.42) | APPNFE2L2 | |
| SCHEMBL10454309 | 0.78 | APP (0.57) | APPLMNAMEN1THRBBLM | |
| SCHEMBL7660222 | 0.76 | LMNA (0.59) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL197669 | 0.74 | MAPT (0.57) | APPLMNATDP1MAPTNFE2L2 | |
| SCHEMBL11042660 | 0.74 | HSD11B1 (0.53) | LMNAMEN1THRBBLMKMT2A | |
| SCHEMBL2121342 | 0.74 | ALDH1A1 (0.52) | LMNAMEN1BLMKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |