Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11043941 | 0.78 | ALDH1A1 (0.36) | ALDH1A1HPGDMAPTGAABCHE | |
| SCHEMBL5573133 | 0.70 | ALDH1A1 (0.44) | ALDH1A1MAPTHTTGAABCHE | |
| SCHEMBL11425713 | 0.69 | GPBAR1 (0.50) | ALDH1A1HPGDGAASMN1; SMN2 | |
| SCHEMBL11255607 | 0.68 | MAPT (0.56) | ALDH1A1MAPTHTTGAAKMT2A | |
| SCHEMBL11268426 | 0.68 | HTT (0.52) | ALDH1A1HPGDMAPTHTTGAA | |
| SCHEMBL11424950 | 0.67 | BCHE (0.40) | ALDH1A1BCHEKMT2ARAB9AMEN1 | |
| SCHEMBL18485421 | 0.67 | KMT2A (0.45) | ALDH1A1MAPTHTTTP53L3MBTL1 | |
| SCHEMBL13642348 | 0.66 | GBA2 (0.34) | BCHE | |
| SCHEMBL5569659 | 0.66 | KMT2A (0.44) | ALDH1A1TP53L3MBTL1GAABCHE | |
| SCHEMBL10770483 | 0.65 | POLB (0.51) | ALDH1A1MAPTHTTTP53L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4465844-A | PEPTIDE, GERMICIDE, DISINFECTANT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-08-14 | — | — | US | disclosed |
| US-4436918-A | FROM A 2,5-DIOXOPYRROLIDINE COMPOUND | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1984-03-13 | — | — | US | disclosed |