SCHEMBL11043941

SCHEMBL11043941

CCOC(=O)N1C(=O)CC(Br)C1=O

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.36
GAA P10253 5/20 0.35
BCHE P06276 1/20 0.35
HPGD P15428 2/20 0.34
KMT2A Q03164 2/20 0.34
KDM4E B2RXH2 1/20 0.34
MEN1 O00255 1/20 0.34
MAPT P10636 1/20 0.34
HSD17B10 Q99714 1/20 0.34
RAB9A P51151 1/20 0.34
NPC1 O15118 1/20 0.34
TSHR P16473 1/20 0.33
NFKB1 P19838 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
GLA P06280 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL11043936 0.78 ALDH1A1 (0.42) ALDH1A1GAABCHEHPGDKMT2A
SCHEMBL5573133 0.71 ALDH1A1 (0.44) ALDH1A1GAABCHEKMT2AKDM4E
SCHEMBL11425713 0.70 GPBAR1 (0.50) ALDH1A1GAAHPGDSMN1; SMN2
SCHEMBL11268426 0.69 HTT (0.52) ALDH1A1GAAHPGDKMT2AKDM4E
SCHEMBL11255607 0.69 MAPT (0.56) ALDH1A1GAAKMT2AKDM4EMEN1
SCHEMBL11424950 0.68 BCHE (0.40) ALDH1A1BCHEKMT2AMEN1RAB9A
SCHEMBL18485421 0.68 KMT2A (0.45) ALDH1A1KMT2AMAPTTSHRSMN1; SMN2
SCHEMBL11261631 0.68 GAA (0.51) ALDH1A1GAAHPGDKMT2AKDM4E
SCHEMBL13642348 0.67 GBA2 (0.34) BCHE
SCHEMBL5569659 0.67 KMT2A (0.44) ALDH1A1GAABCHEKMT2AHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4465844-A PEPTIDE, GERMICIDE, DISINFECTANT TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-08-14 US disclosed
US-4436918-A FROM A 2,5-DIOXOPYRROLIDINE COMPOUND TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1984-03-13 US disclosed