Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RXRA | P19793 | 1/20 | 0.51 |
| ▸ | RXRB | P28702 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8780311 | 0.87 | ALDH1A1 (0.57) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL11520997 | 0.83 | HPGD (0.50) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL5139133 | 0.82 | HPGD (0.68) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL9448786 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL307233 | 0.81 | KMT2A (0.75) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL29505934 | 0.81 | KMT2A (0.75) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL29505938 | 0.81 | KMT2A (0.75) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL1333545 | 0.81 | KMT2A (0.75) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL11044043 | 0.81 | HPGD (0.51) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT | |
| SCHEMBL5823575 | 0.80 | MAPT (0.66) | SMN1; SMN2ALDH1A1HPGDKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4487772-A | CARDIOTONIC AGENTS | OTSUKA PHARMACEUTICAL CO. LTD. (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4468402-A | Carbostyril derivatives, process for producing the same and cardiotonic compositions containing the same | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-08-28 | — | — | US | disclosed |
| US-4454130-A | CARDIOTONIC, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |