Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9448898 | 0.83 | ABCG2 (0.59) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 | |
| SCHEMBL9448934 | 0.81 | KMT2A (0.56) | ALDH1A1KMT2AKDM4EMAPTMEN1 | |
| SCHEMBL8780311 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HPGDSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL11044054 | 0.81 | SMN1; SMN2 (0.54) | ALDH1A1HPGDSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL8870318 | 0.81 | KMT2A (0.50) | ALDH1A1SMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL9448901 | 0.79 | AKR1C3 (0.60) | ALDH1A1SMN1; SMN2KDM4ELMNANPC1 | |
| SCHEMBL29693792 | 0.78 | RAB9A (0.47) | ALDH1A1SMN1; SMN2KMT2AKDM4EMAPT | |
| SCHEMBL11520997 | 0.78 | HPGD (0.50) | ALDH1A1HPGDSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL5139133 | 0.77 | HPGD (0.68) | ALDH1A1HPGDSMN1; SMN2KMT2AKDM4E | |
| SCHEMBL9449177 | 0.77 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0466730-B1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1993-07-21 | — | — | EP | disclosed |
| US-5220021-A | Geminal bisphosphonic acids and derivatives as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0466730-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS. | UPJOHN CO (US) | 1992-01-22 | — | — | EP | disclosed |
| WO-1990012017-A1 | GEMINAL BISPHOSPHONIC ACIDS AND DERIVATIVES AS ANTI-ARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1990-10-18 | — | — | WO | disclosed |