Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11169123 | 0.92 | LMNA (0.42) | TP53LMNACYP3A4AURKACHRM1 | |
| SCHEMBL11039376 | 0.90 | TP53 (0.46) | TP53LMNACYP3A4MEN1KMT2A | |
| SCHEMBL11053089 | 0.90 | LMNA (0.44) | TP53LMNADRD3OPRK1SLC22A1 | |
| SCHEMBL11057804 | 0.89 | LMNA (0.44) | TP53LMNADRD3OPRK1SLC22A1 | |
| SCHEMBL11160221 | 0.88 | TP53 (0.44) | TP53LMNACYP3A4MEN1KMT2A | |
| SCHEMBL11162886 | 0.88 | LMNA (0.43) | TP53LMNADRD3OPRK1SLC22A1 | |
| SCHEMBL11046042 | 0.86 | TP53 (0.43) | TP53LMNAMEN1KMT2AAURKA | |
| SCHEMBL11169424 | 0.85 | GABRA1 (0.40) | TP53LMNAMEN1KMT2AAURKA | |
| SCHEMBL11041566 | 0.84 | GABRA1 (0.41) | TP53LMNACYP3A4GAAKMT2A | |
| SCHEMBL11168051 | 0.84 | GABRA1 (0.41) | TP53LMNAOPRK1PDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041242-B1 | CARBAMOYLOXYAMINO-1,4-BENZODIAZEPINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-11 | — | — | EP | disclosed |
| US-4395409-A | ANXIOLYTIC AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-26 | — | — | US | disclosed |