Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | GHSR | Q92847 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11053089 | 0.97 | LMNA (0.44) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11039376 | 0.95 | TP53 (0.46) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11160221 | 0.93 | TP53 (0.44) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11169123 | 0.92 | LMNA (0.42) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11046042 | 0.91 | TP53 (0.43) | LMNAAURKATP53CHRM1 | |
| SCHEMBL11041566 | 0.91 | GABRA1 (0.41) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11044384 | 0.89 | TP53 (0.41) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11168627 | 0.88 | MEN1 (0.42) | LMNAAURKATP53CHRM1CYP3A4 | |
| SCHEMBL11043502 | 0.88 | NPSR1 (0.44) | TP53CHRM1OPRK1PDE4DKCNH2 | |
| SCHEMBL11171819 | 0.88 | LMNA (0.42) | LMNAAURKATP53CHRM1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0041242-B1 | CARBAMOYLOXYAMINO-1,4-BENZODIAZEPINES, THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-07-11 | — | — | EP | disclosed |
| US-4395409-A | ANXIOLYTIC AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-07-26 | — | — | US | disclosed |
| EP-0041242-A1 | Carbamoyloxyamino-1,4-benzodiazepines, their preparation and medicines containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-12-09 | — | — | EP | disclosed |