SCHEMBL11044528

SCHEMBL11044528

c1ccc(P(CC[Si](CCP(c2ccccc2)c2ccccc2)(CCP(c2ccccc2)c2ccccc2)CCP(c2ccccc2)c2ccccc2)c2ccccc2)cc1

nearest known ligand 0.39

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
ESR1 P03372 2/20 0.31
ESR2 Q92731 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10732408 0.89 CYP3A4 (0.32) CYP3A4TDP1
SCHEMBL11048141 0.87 CYP3A4 (0.33) CYP3A4TDP1
SCHEMBL10709552 0.81 CYP3A4 (0.36) CYP3A4TDP1KDM4EGAAESR1
SCHEMBL11044338 0.81 CYP3A4 (0.36) CYP3A4TDP1KDM4EGAAESR1
SCHEMBL17431935 0.81 CYP3A4 (0.36) CYP3A4TDP1KDM4EGAAESR1
SCHEMBL5898753 0.81 CYP3A4 (0.36) CYP3A4TDP1KDM4EGAA
SCHEMBL10728260 0.81 CYP3A4 (0.36) CYP3A4TDP1KDM4EGAAESR1
SCHEMBL27343 0.81 CYP3A4 (0.50) CYP3A4TDP1KDM4EGAAESR1
Hydrochloric Acid SCHEMBL10384718 0.79 CYP3A4 (0.35) CYP3A4TDP1
SCHEMBL11044967 0.79 CYP3A4 (0.35) CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4480137-A ALDEHYDES FROM ALPHA-OLEFINS; HEAT RESISTANCE; CATALYST SELECTIVITY EXXON RESEARCH & ENGINEERING COMPANY (US) 1984-10-30 US disclosed
US-4454353-A Trihydrocarbyl silyl substituted alkyl diaryl phosphine transition metal complexes and their use as homogeneous hydroformylation-aldolization catalysts EXXON RESEARCH AND ENGINEERING CO. (US) 1984-06-12 US disclosed
US-4451673-A REACTING OLEFINS WITH CARBON MONOXIDE AND HYDROGEN TO YIELD ALDEHYDES EXXON RESEARCH AND ENGINEERING CO. (US) 1984-05-29 US disclosed
US-4450299-A ALDEHYDES FROM UNSATURATED ACYCLIC HYDROCARBONS, CARBON MONOXIDE AND HYDROGEN EXXON RESEARCH AND ENGINEERING CO. (US) 1984-05-22 US disclosed