Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.53 |
| ▸ | OPRL1 | P41146 | 11/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11030906 | 0.81 | OPRL1 (0.52) | OPRL1OPRM1OPRK1ALDH1A1KDM4E | |
| SCHEMBL11031463 | 0.80 | HSD11B1 (0.74) | MAOBOPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL11101766 | 0.75 | KMT2A (0.58) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL11099453 | 0.73 | HSD11B1 (0.54) | MAOBOPRL1OPRM1OPRK1ALDH1A1 | |
| SCHEMBL11105124 | 0.73 | MAOB (0.55) | MAOBOPRM1OPRK1ALDH1A1KDM4E | |
| SCHEMBL11097138 | 0.72 | MAOB (0.54) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL11104105 | 0.72 | MAOB (0.53) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL11031460 | 0.72 | ALDH1A1 (0.55) | MAOBOPRM1OPRK1ALDH1A1KDM4E | |
| SCHEMBL11104442 | 0.70 | MAOB (0.54) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL10733471 | 0.69 | MAPT (0.78) | MAOBALDH1A1KDM4ENPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4446141-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO. (JP) | 1984-05-01 | — | — | US | disclosed |
| EP-0018417-B1 | NOVEL PIPERIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1982-06-30 | — | — | EP | disclosed |
| EP-0018417-A1 | Novel piperidine derivatives and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1980-11-12 | — | — | EP | disclosed |