Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.46 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11031463 | 0.85 | HSD11B1 (0.74) | HSD11B1MAOBOPRM1OPRK1OPRD1 | |
| SCHEMBL11106966 | 0.81 | OPRM1 (0.50) | HSD11B1OPRM1OPRK1OPRD1OPRL1 | |
| SCHEMBL11104730 | 0.75 | MAOB (0.46) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL11104724 | 0.75 | MAOB (0.46) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL11045230 | 0.73 | MAOB (0.53) | HSD11B1MAOBOPRM1OPRK1OPRD1 | |
| SCHEMBL11101766 | 0.73 | KMT2A (0.58) | MAOBALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL5777516 | 0.70 | PLD2 (0.68) | OPRM1OPRK1OPRL1ADRA1ACHRM2 | |
| SCHEMBL11430686 | 0.69 | PLD2 (0.61) | HSD11B1OPRM1OPRK1OPRL1ADRA1A | |
| SCHEMBL11033245 | 0.69 | PLD2 (0.71) | HSD11B1OPRM1OPRK1OPRL1ADRA1A | |
| SCHEMBL11268724 | 0.69 | OPRK1 (0.58) | HSD11B1OPRM1OPRK1OPRL1ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0029707-B1 | NOVEL PIPERIDINE DERIVATIVES, METHOD FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | KYOWA HAKKO KOGYO CO., LTD (JP) | 1984-02-01 | — | — | EP | disclosed |
| US-4410528-A | Hypotensive piperidine derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1983-10-18 | — | — | US | disclosed |
| EP-0029707-A1 | Novel piperidine derivatives, method for the preparation thereof and pharmaceutical compositions containing them | KYOWA HAKKO KOGYO CO., LTD (JP) | 1981-06-03 | — | — | EP | disclosed |