Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11038402 | 0.86 | ALOX5 (0.44) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL7621307 | 0.86 | ALOX5 (0.48) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11040057 | 0.82 | PTGS2 (0.48) | ALDH1A1MAPTKDM4EGAANPSR1 | |
| SCHEMBL11707308 | 0.81 | ALDH1A1 (0.51) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11704670 | 0.81 | HTR7 (0.60) | ALDH1A1MAPTCYP1A2CYP2C19CYP2C9 | |
| SCHEMBL11040051 | 0.81 | ALDH1A1 (0.58) | ALDH1A1MAPTCYP1A2KDM4ECYP3A4 | |
| SCHEMBL11040891 | 0.81 | HRH3 (0.56) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL10787518 | 0.80 | PTGS1 (0.52) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL543986 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 | |
| SCHEMBL11039848 | 0.80 | HRH3 (0.58) | ALDH1A1MAPTCYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | claimed |
| US-4451471-A | Certain 2,4,5-tri-substituted thiazoles, pharmaceutical compositions containing same and methods of using same | CIBA-GEIGY CORPORATION (US) | 1984-05-29 | — | — | US | disclosed |
| EP-0061425-A2 | Thiazole derivatives, processes for their preparation, medicaments containing them and their use | CIBA-GEIGY AG (CH) | 1982-09-29 | — | — | EP | disclosed |
| US-4022607-A | Substituted oxazoles and thiazoles as herbicides | SANDOZ, INC. (US) | 1977-05-10 | — | — | US | disclosed |