Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 2/20 | 0.41 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | TNF | P01375 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.35 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10753288 | 0.77 | MAT2A (0.49) | MAT2ATSHRKDM4EMAPK1HSP90AB1 | |
| SCHEMBL22393655 | 0.72 | HTT (0.51) | TNFHTTDHODHMAPTLMNA | |
| SCHEMBL8013228 | 0.70 | PDE5A (0.52) | POLBTSHRKDM4EHTTSMN1; SMN2 | |
| SCHEMBL405341 | 0.70 | KDM4E (0.44) | MAT2AGAAKDM4EMAPK1NPC1 | |
| SCHEMBL30013869 | 0.70 | KDM4E (0.44) | MAT2AGAAKDM4EMAPK1NPC1 | |
| SCHEMBL15537639 | 0.70 | PDE10A (0.42) | NPC1RAB9A | |
| SCHEMBL20561018 | 0.67 | DHODH (0.42) | MAT2AGAAKDM4EMAPK1NPC1 | |
| SCHEMBL8361293 | 0.67 | ALDH1A1 (0.42) | GAAPOLBKDM4EMAPK1NPC1 | |
| SCHEMBL21500731 | 0.67 | HTT (0.68) | HTTNR4A2HSP90AB1ALDH1A1 | |
| SCHEMBL14189290 | 0.67 | MPO (0.57) | MAT2APOLBKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4451448-A | 1-Substituted tricyclic quinazolinones useful as tranquilizers | SANDOZ, INC. (US) | 1984-05-29 | — | — | US | disclosed |