Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL585916 | 0.76 | HDAC8 (0.39) | NPC1POLBRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL2454796 | 0.76 | NPC1 (0.36) | NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL3319557 | 0.75 | CHAT (0.45) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL25592875 | 0.74 | ACHE (0.31) | — | |
| SCHEMBL9289232 | 0.73 | — | — | |
| SCHEMBL1164410 | 0.73 | — | — | |
| Iodide SCHEMBL2713208 | 0.71 | HDAC8 (0.39) | NPC1POLBRAB9ASMN1; SMN2 | |
| Bromide SCHEMBL2494675 | 0.71 | NPC1 (0.41) | NPC1POLBRAB9ASMN1; SMN2 | |
| SCHEMBL28731818 | 0.70 | NPC1 (0.35) | NPC1POLBRAB9ASMN1; SMN2 | |
| Ammonia Solution, Strong SCHEMBL28760022 | 0.68 | NPC1 (0.34) | NPC1POLBRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4439322-A | IONIC COPOLYMER | TORAY INDUSTRIES, INC. (JP) | 1984-03-27 | — | — | US | claimed |
| US-4439322-A | IONIC COPOLYMER | TORAY INDUSTRIES, INC. (JP) | 1984-03-27 | — | — | US | disclosed |