Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10921170 | 0.88 | ACE (0.43) | ACE | |
| SCHEMBL7343593 | 0.84 | NOTUM (0.50) | ACEMTNR1ANOTUMAGTR2HSD17B10 | |
| SCHEMBL7343587 | 0.84 | NOTUM (0.50) | ACEMTNR1ANOTUMAGTR2HSD17B10 | |
| SCHEMBL11047768 | 0.82 | MTNR1A (0.38) | MTNR1ANOTUMMAPK1HSD17B10ALDH1A1 | |
| SCHEMBL11045686 | 0.81 | KMT2A (0.49) | ACEMTNR1AAGTR2ALDH1A1LMNA | |
| SCHEMBL7305955 | 0.81 | MTNR1A (0.48) | ACEMTNR1ANOTUMAGTR2HSD17B10 | |
| SCHEMBL8742789 | 0.81 | MTNR1A (0.48) | ACEMTNR1ANOTUMAGTR2HSD17B10 | |
| SCHEMBL11045722 | 0.79 | ACE (0.64) | ACE | |
| SCHEMBL11045862 | 0.79 | ACE (0.64) | ACE | |
| SCHEMBL11049197 | 0.78 | ACE (0.62) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | claimed |
| US-4461896-A | 1-[Acylthio) and (mercapto)-1-oxoalkyl]-1,2,3,4-tetrahydroquinoline-2-carboxylic acids | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1984-07-24 | — | — | US | disclosed |