SCHEMBL11047986

SCHEMBL11047986

C=CC[C@H]1CC[C@H]([C@H]2CC[C@H]([C@H]3CC[C@H](OC(=O)c4cccc(C(F)(F)F)c4)CC3)CC2)CC1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
KDM4E B2RXH2 1/20 0.48
ALDH1A1 P00352 1/20 0.48
HPGD P15428 1/20 0.48
CES2 O00748 1/20 0.41
CNR2 P34972 5/20 0.40
GAA P10253 1/20 0.39
MAPT P10636 1/20 0.39
LMNA P02545 2/20 0.39
KMT2A Q03164 2/20 0.38
HTT P42858 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HSD11B1 P28845 1/20 0.38
CHRM2 P08172 1/20 0.37
CHRM4 P08173 1/20 0.37
CHRM3 P20309 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11499667 0.82 MEN1 (0.48) CYP2C9CYP2C19GAAMAPTKMT2A
SCHEMBL9299353 0.78 HPGD (0.60) CYP2C9CYP2C19KDM4EALDH1A1HPGD
SCHEMBL9854916 0.78 MEN1 (0.51) CYP2C9CYP2C19GAAMAPTLMNA
SCHEMBL11138823 0.78 CCR2 (0.43) ALDH1A1CES2
SCHEMBL28968096 0.78 ALDH1A1 (0.56) CYP2C9CYP2C19KDM4EALDH1A1HPGD
SCHEMBL11042461 0.77 KMT2A (0.40) MAPTKMT2A
SCHEMBL18455052 0.76 CYP2C9 (0.54) CYP2C9CYP2C19KDM4EALDH1A1HPGD
SCHEMBL7412588 0.75 CYP2C9 (0.56) CYP2C9CYP2C19KDM4EALDH1A1HPGD
SCHEMBL28342942 0.73 HPGD (0.52) CYP2C9CYP2C19KDM4EALDH1A1HPGD
SCHEMBL14780442 0.72 CES2 (0.56) CYP2C19ALDH1A1HPGDCES2GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59095242-A None JP disclosed
JP-S5995242-A ESTER DERIVATIVE CONTAINING TRIFLUOROMETHYL GROUP CHISSO CORP 1984-06-01 JP disclosed