Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | RAB9A | P51151 | 4/20 | 0.61 |
| ▸ | NPC1 | O15118 | 3/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bendacalol SCHEMBL11047717 | 0.81 | LMNA (0.52) | SMN1; SMN2HPGDALDH1A1MAPTLMNA | |
| Bendacalol SCHEMBL11050612 | 0.79 | LMNA (0.51) | SMN1; SMN2HPGDALDH1A1MAPTLMNA | |
| SCHEMBL7441442 | 0.78 | LMNA (0.50) | SMN1; SMN2ALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL11046528 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2RAB9ANPC1HPGDCYP2C19 | |
| Bendacalol SCHEMBL29400550 | 0.76 | LMNA (0.52) | SMN1; SMN2HPGDALDH1A1MAPTLMNA | |
| Bendacalol SCHEMBL588993 | 0.76 | LMNA (0.52) | SMN1; SMN2HPGDALDH1A1MAPTLMNA | |
| SCHEMBL7435319 | 0.76 | EPHX1 (0.47) | SMN1; SMN2RAB9ANPC1HPGDCYP2C19 | |
| SCHEMBL11469283 | 0.76 | MAPT (0.52) | SMN1; SMN2RAB9ANPC1HPGDMAPT | |
| SCHEMBL16492844 | 0.76 | ADRB2 (0.46) | SMN1; SMN2RAB9AHPGDALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11044563 | 0.75 | POLB (0.50) | SMN1; SMN2HPGDALDH1A1ALOX12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4471127-A | 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | claimed |
| EP-0050585-B1 | 1,5-BIS-(1,4-BENZODIOXIN-2-YL)-3-AZAPENTANE-1,5 DIOLS, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR THERAPEUTICAL USE | CIBA-GEIGY AG (CH) | 1984-10-03 | — | — | EP | disclosed |
| US-4471127-A | 1-5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4471128-A | 1,5-Bis-(1,4-benzodioxin-2-yl)-3-azapentane-1,5-diols | CIBA-GEIGY CORPORATION (US) | 1984-09-11 | — | — | US | disclosed |
| US-4380653-A | HYPOTENSIVES, CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1983-04-19 | — | — | US | disclosed |