SCHEMBL11048833

SCHEMBL11048833

COc1ccccc1NC(=O)Nc1ccc(NNC(=O)I)cc1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 8/20 0.68
MAPT P10636 8/20 0.68
NPC1 O15118 6/20 0.68
SMN1; SMN2 Q16637 5/20 0.68
L3MBTL1 Q9Y468 1/20 0.64
MEN1 O00255 5/20 0.62
KMT2A Q03164 5/20 0.62
ALDH1A1 P00352 2/20 0.62
CA12 O43570 1/20 0.61
CA1 P00915 1/20 0.61
CA2 P00918 1/20 0.61
CA9 Q16790 1/20 0.61
THRB P10828 1/20 0.58
LMNA P02545 2/20 0.57
TP53 P04637 1/20 0.57
PKM P14618 1/20 0.57
POLB P06746 2/20 0.56
HPGD P15428 1/20 0.56
NPSR1 Q6W5P4 1/20 0.56
AHR P35869 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5852135 0.81 MAPT (0.78) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL11006683 0.81 RAB9A (0.78) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL7765963 0.81 RAB9A (0.68) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL4554983 0.81 POLB (0.77) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL31040567 0.81 POLB (0.77) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL15535634 0.80 RAB9A (0.76) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL11895728 0.80 RAB9A (0.76) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1
SCHEMBL11044141 0.80 RAB9A (0.71) RAB9AMAPTNPC1SMN1; SMN2MEN1
SCHEMBL11047148 0.79 MAOA (0.63) RAB9AMAPTNPC1SMN1; SMN2MEN1
SCHEMBL15652376 0.78 RAB9A (0.72) RAB9AMAPTNPC1SMN1; SMN2L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4481285-A IMPROVED SHAPPNESS AND EDGE EFFECTS FUJI PHOTO FILM CO., LTD. (JP) 1984-11-06 US disclosed