Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.75 |
| ▸ | MAPT | P10636 | 4/20 | 0.75 |
| ▸ | RAB9A | P51151 | 3/20 | 0.75 |
| ▸ | NPC1 | O15118 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | HTT | P42858 | 1/20 | 0.71 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.69 |
| ▸ | AHR | P35869 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31040567 | 1.00 | POLB (0.77) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL13923626 | 0.90 | SMN1; SMN2 (0.68) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL23331399 | 0.89 | ALDH1A1 (0.66) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL9036508 | 0.89 | ALDH1A1 (0.71) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL7759449 | 0.89 | ALDH1A1 (0.66) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL1463287 | 0.88 | GRIK1 (0.72) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL6850954 | 0.88 | ALDH1A1 (0.71) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| Hydrochloric Acid SCHEMBL9004628 | 0.87 | ALDH1A1 (0.69) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL18120560 | 0.87 | MEN1 (0.75) | POLBSMN1; SMN2MAPTRAB9ANPC1 | |
| SCHEMBL11006683 | 0.87 | RAB9A (0.78) | POLBSMN1; SMN2MAPTRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| EP-0971987-B1 | INK COMPOSITION CONTAINING AT LEAST TWO AZO DYES | AVECIA LTD (GB) | 2002-07-17 | — | — | EP | disclosed |
| US-6251174-B1 | INK JET PRINTING PROCESS | AVECIA LIMITED (GB) | 2001-06-26 | — | — | US | disclosed |
| EP-0971987-A1 | INK COMPOSITION CONTAINING AT LEAST TWO AZO DYES | Avecia Limited (GB) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998044053-A1 | INK COMPOSITION CONTAINING AT LEAST TWO AZO DYES | AVECIA LIMITED (GB) | 1998-10-08 | — | — | WO | disclosed |
| EP-0477819-B1 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-03-15 | — | — | EP | disclosed |
| US-5200422-A | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-04-06 | — | — | US | disclosed |
| EP-0477819-A2 | Benzimidazole derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-04-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | POLB 249/4885SMN1; SMN2 850/4885MAPT 1631/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | POLB 249/4885SMN1; SMN2 850/4885MAPT 1631/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.