Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 9/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RGS12 | O14924 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3454286 | 0.98 | THRB (0.57) | THRBCA2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11790415 | 0.91 | THRB (0.51) | THRBCA2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11674093 | 0.84 | PTGDR2 (0.49) | THRBPTGDR2PTGDRPTGER2SLC22A12 | |
| SCHEMBL11831779 | 0.82 | THRB (0.46) | THRBCA2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11834367 | 0.82 | THRB (0.45) | THRBPTGDR2PTGDRPTGER2SIGMAR1 | |
| SCHEMBL11567034 | 0.82 | PTGDR (0.52) | THRBPTGDR2PTGDRPTGER2EPHX2 | |
| SCHEMBL11837224 | 0.80 | THRB (0.43) | THRBPTGDR2PTGDRPTGER2SIGMAR1 | |
| SCHEMBL11854162 | 0.80 | LDHA (0.45) | THRBPTGDR2PTGDROPRK1KDM4E | |
| SCHEMBL3900326 | 0.80 | NUDT1 (0.43) | THRBSLC6A2SLC6A4SLC6A3PTGDR2 | |
| SCHEMBL7796460 | 0.79 | THRB (0.62) | THRBCA2PTGDR2PTGDRPTGER2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0106649-A2 | Prostaglandins and their use | THE UPJOHN COMPANY (US) | 1984-04-25 | — | — | EP | disclosed |
| US-4439445-A | ULCER PROPHYLAXIS | THE UPJOHN COMPANY (US) | 1984-03-27 | — | — | US | disclosed |
| US-4424227-A | Gastric cytoprotection with heterocyclic sulfonamides | THE UPJOHN COMPANY (US) | 1984-01-03 | — | — | US | disclosed |
| US-4397865-A | INDUCED BY NON-STEROIDAL ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1983-08-09 | — | — | US | disclosed |
| US-4061742-A | Method of reducing the undesirable gastrointestinal effects of prostaglandin synthetase inhibitors with PGA compounds | THE UPJOHN COMPANY (US) | 1977-12-06 | — | — | US | disclosed |
| US-4011332-A | RODENTICIDE | BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DT) | 1977-03-08 | — | — | US | disclosed |