Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | LOX | P28300 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1104957 | 0.79 | ALDH1A1 (0.39) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL1104964 | 0.79 | CA2 (0.59) | SMN1; SMN2HTTALDH1A1 | |
| SCHEMBL20733374 | 0.77 | LMNA (0.66) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL1104955 | 0.76 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2HTTALDH1A1MAPT | |
| SCHEMBL1104970 | 0.75 | LMNA (0.35) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL19001352 | 0.74 | CA12 (0.64) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL691734 | 0.74 | ALDH1A1 (0.73) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL7629089 | 0.71 | LMNA (0.63) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL1104968 | 0.70 | TDP1 (0.37) | LMNASMN1; SMN2HTTALDH1A1RAB9A | |
| SCHEMBL4482607 | 0.70 | LMNA (0.60) | LMNASMN1; SMN2HTTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8907101-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2014-12-09 | — | — | US | disclosed |
| US-8153814-B2 | Sulfonamide derivatives | PFIZER LIMITED (GB) | 2012-04-10 | — | — | US | disclosed |