SCHEMBL691734

SCHEMBL691734

COc1ccc(S(=O)(=O)N(C)C)cc1

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.73
LMNA P02545 3/20 0.73
SMN1; SMN2 Q16637 2/20 0.73
HTT P42858 1/20 0.73
PKM P14618 3/20 0.61
KEAP1 Q14145 2/20 0.59
PGR P06401 1/20 0.56
TSHR P16473 1/20 0.54
MAPT P10636 2/20 0.53
GAA P10253 2/20 0.53
HTR2A P28223 1/20 0.53
HTR2C P28335 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
OPRM1 P35372 1/20 0.52
OPRD1 P41143 1/20 0.52
CA1 P00915 1/20 0.52
CA2 P00918 1/20 0.52
MMP1 P03956 1/20 0.52
MMP2 P08253 1/20 0.52
MMP9 P14780 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10449139 0.83 PKM (0.57) ALDH1A1LMNASMN1; SMN2HTTPKM
SCHEMBL5622356 0.82 PGR (0.79) ALDH1A1LMNAPKMKEAP1PGR
SCHEMBL20960702 0.79 TUBB4A (0.52) ALDH1A1LMNASMN1; SMN2HTTPKM
SCHEMBL7770162 0.79 KEAP1 (0.60) HTTPKMKEAP1PGRNFE2L2
SCHEMBL23536525 0.78 ALDH1A1 (0.66) ALDH1A1LMNASMN1; SMN2HTTKEAP1
SCHEMBL10950108 0.78 LMNA (0.85) ALDH1A1LMNASMN1; SMN2HTTPGR
SCHEMBL20733374 0.78 LMNA (0.66) ALDH1A1LMNASMN1; SMN2HTTPKM
SCHEMBL5612071 0.78 LMNA (0.85) ALDH1A1LMNASMN1; SMN2HTTPGR
SCHEMBL4204765 0.78 LMNA (0.76) ALDH1A1LMNASMN1; SMN2HTTPKM
SCHEMBL10872609 0.78 PKM (0.55) ALDH1A1LMNASMN1; SMN2HTTPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 79 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0694041-A1 A PROCESS AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS CONTAINING N-ALPHA-METHYLARGININE THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) 1996-01-31 EP claimed
CN-117535689-A Method for synthesizing sulfonamide through decarbonylation of N, N-dimethylformamide and denitrification of sulfonyl hydrazide under electrochemical condition 湘潭大学 2024-02-09 CN disclosed
WO-2023220737-A2 OLIGONUCLEOTIDES HAVING A SYNTHETIC BACKBONE AND SYNTHESIS THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-11-16 WO disclosed
WO-2023196342-A1 α4β1/7 INTEGRIN LIGAND CONJUGATED COMPOUNDS AND USES THEREOF ADARX PHARMACEUTICALS, INC. (US) 2023-10-12 WO disclosed
WO-2023146989-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed
WO-2023096904-A2 C-16 MODIFIED TRIOXACARCINS, ANTIBODY DRUG CONJUGATES, AND USES THEREOF PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2023-06-01 WO disclosed
EP-4164752-A1 INHIBITORS OF TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2023-04-19 EP disclosed
EP-4161651-A1 QUINAZOLINE-DERIVED HCK INHIBITORS FOR USE IN THE TREATMENT OF MYD88 MUTATED DISEASES Dana-Farber Cancer Institute, Inc. (US) 2023-04-12 EP disclosed
EP-4081202-A1 TRANSCRIPTIONAL ENHANCED ASSOCIATE DOMAIN (TEAD) TRANSCRIPTION FACTOR INHIBITORS AND USES THEREOF Dana-Farber Cancer Institute, Inc. (US) 2022-11-02 EP disclosed
EP-4027993-A1 CYCLOOXYGENASE-2 INHIBITORS AND USES THEREOF The Broad Institute Inc. (US) 2022-07-20 EP disclosed
US-5681840-A ANTIDOPAMINERGIC AGENTS ZENECA LIMITED (GB) 1997-10-28 US disclosed
EP-0532177-B1 Methanoanthracenes as dopamine antagonists ZENECA LTD (GB) 1996-10-16 EP disclosed
EP-0533344-B1 Methanoanthracenes as dopamine antagonists ZENECA LTD (GB) 1996-10-16 EP disclosed
US-5550136-A ANTAGONISTS OF DOPAMINE D-2 RECEPTORS ZENECA LIMITED (GB) 1996-08-27 US disclosed
US-5512575-A ANTISEROTONINE AGENT ZENECA LIMITED (GB) 1996-04-30 US disclosed
EP-0389861-B1 Benzopyran derivatives and processes for preparation thereof FUJISAWA PHARMACEUTICAL CO (JP) 1995-08-23 EP disclosed
US-5399568-A Dopamine antagonists IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1995-03-21 US disclosed
EP-0532177-A1 Methanoanthracenes as dopamine antagonists ZENECA LIMITED (GB) 1993-03-17 EP disclosed
US-5104890-A Potassium channel activtors; vasodilators FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-04-14 US disclosed
EP-0389861-A1 Benzopyran derivatives and processes for preparation thereof FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-10-03 EP disclosed