Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | MTHFD2 | P13995 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10860457 | 0.98 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL11449986 | 0.98 | GAA (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL10858250 | 0.96 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL10856015 | 0.96 | ALDH1A1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| Hydrochloric Acid SCHEMBL10856957 | 0.95 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| Perchlorate SCHEMBL10863084 | 0.88 | ALDH1A1 (0.48) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL17624388 | 0.74 | MTHFD2 (0.48) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL10613505 | 0.70 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL19498216 | 0.69 | MTHFD2 (0.44) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL17624124 | 0.69 | MTHFD2 (0.44) | SMN1; SMN2ALDH1A1NPC1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4472399-A | Indolo[2',3';3,4]pyrido[2,1-b]quinazoline-5-ones, a process for the preparation thereof, and diuretic compositions and methods using them | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1984-09-18 | — | — | US | disclosed |
| US-4395549-A | CHEMICAL INTERMEDIATES FOR RUTECARPINE DIURETICS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) | 1983-07-26 | — | — | US | disclosed |
| US-4220771-A | MORPHINE POTENTIATORS | CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT (HU) | 1980-09-02 | — | — | US | disclosed |