Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | HK1 | P19367 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11046960 | 0.77 | ALDH1A1 (0.54) | SMN1; SMN2PDE4BPDE7AALDH1A1MAPT | |
| SCHEMBL11046962 | 0.70 | HSD17B10 (0.44) | SMN1; SMN2NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL3414928 | 0.69 | NPSR1 (0.45) | SMN1; SMN2NPC1RAB9AALDH1A1MAPT | |
| SCHEMBL7886055 | 0.69 | MAPT (0.39) | SMN1; SMN2PDE4BPDE7AKDM4EALDH1A1 | |
| SCHEMBL11048979 | 0.68 | QPCT (0.52) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL19073030 | 0.67 | KAT2B (0.43) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL30765704 | 0.67 | KDM4E (0.43) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL31751071 | 0.66 | KDM4E (0.31) | KDM4EALDH1A1 | |
| SCHEMBL31751753 | 0.66 | SMN1; SMN2 (0.33) | SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL11048982 | 0.63 | KDM4E (0.37) | SMN1; SMN2NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442289-A | ANTIASTHMA | HOFFMANN-LA ROCHE INC. (US) | 1984-04-10 | — | — | US | claimed |
| US-4442289-A | ANTIASTHMA | HOFFMANN-LA ROCHE INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4376121-A | Antiallerigically-active imidazothienopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |