Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | QPCT | Q16769 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11048979 | 0.80 | QPCT (0.52) | KDM4ESMN1; SMN2QPCTNPC1RAB9A | |
| SCHEMBL11045234 | 0.76 | GRIK1 (0.45) | KDM4ESMN1; SMN2ALDH1A1HSD17B10MAPT | |
| SCHEMBL11045232 | 0.68 | ALDH1A1 (0.60) | SMN1; SMN2QPCTALDH1A1HPGDNPSR1 | |
| SCHEMBL23635683 | 0.64 | SMN1; SMN2 (0.44) | KDM4ESMN1; SMN2ALDH1A1HPGDNPSR1 | |
| SCHEMBL11051146 | 0.63 | SMN1; SMN2 (0.45) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL16599416 | 0.63 | MAPK1 (0.38) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL24961270 | 0.61 | SMN1; SMN2 (0.38) | KDM4ESMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL7643586 | 0.61 | MAPK1 (0.51) | HPGDKMT2A | |
| SCHEMBL14198913 | 0.61 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2NPC1RAB9AKAT2B | |
| SCHEMBL24703554 | 0.60 | KDM4E (0.57) | KDM4ESMN1; SMN2NPC1RAB9AKAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4442289-A | ANTIASTHMA | HOFFMANN-LA ROCHE INC. (US) | 1984-04-10 | — | — | US | disclosed |
| US-4376121-A | Antiallerigically-active imidazothienopyrimidine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1983-03-08 | — | — | US | disclosed |