Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 7/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.34 |
| ▸ | TUBB | P07437 | 2/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10973832 | 0.86 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL4276345 | 0.77 | ALDH1A1 (0.42) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL6535860 | 0.72 | ALDH1A1 (0.49) | ALDH1A1KDM4EL3MBTL1ERN1PDE4B | |
| SCHEMBL11476953 | 0.71 | KDM4E (0.39) | ALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL11395556 | 0.71 | HMGCR (0.59) | — | |
| SCHEMBL10480442 | 0.69 | CSNK2A1 (0.47) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL27812283 | 0.68 | ALDH1A1 (0.41) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL17748416 | 0.66 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL10898345 | 0.66 | PTGS2 (0.41) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL6535983 | 0.65 | ERN1 (0.45) | MEN1KMT2ANPC1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010299-B1 | PHARMACEUTICAL COMPOSITION USEFUL FOR THE TREATMENT OF HYPERCHOLESTEREMIA | MERCK & CO. INC. (US) | 1984-02-15 | — | — | EP | disclosed |