Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.36 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11050055 | 0.91 | KMT2A (0.45) | LMNAHTTKMT2AMEN1MAPK1 | |
| SCHEMBL11052129 | 0.91 | POLB (0.46) | LMNATSHRPOLBHTTLCK | |
| SCHEMBL11580953 | 0.85 | RIPK1 (0.40) | LMNATSHRPOLBLCKDRD2 | |
| SCHEMBL11052138 | 0.85 | KMT2A (0.40) | LMNAHTTKMT2AMEN1MAPK1 | |
| SCHEMBL11049616 | 0.85 | HTT (0.50) | LMNAPOLBHTTKMT2AMEN1 | |
| SCHEMBL11578638 | 0.85 | KMT2A (0.40) | LMNATSHRPOLBLCKDRD2 | |
| SCHEMBL11052870 | 0.85 | PDK1 (0.51) | LMNATSHRPOLBHTTLCK | |
| SCHEMBL11252413 | 0.84 | POLB (0.51) | LMNATSHRPOLBHTTKMT2A | |
| SCHEMBL11579645 | 0.84 | PTGS2 (0.41) | LMNAPOLBHTTKMT2AMEN1 | |
| SCHEMBL11251439 | 0.83 | HTT (0.42) | LMNATSHRHTTLCKKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |