Benzene

Benzene

SCHEMBL11052377

CC1CCCc2nc3c(c(=O)n21)C(=NN)CCC3.c1ccccc1

nearest known ligand 0.30

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
FPR1 P21462 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL11051133 0.78
Benzene SCHEMBL11192509 0.75 MEN1 (0.46) HSD17B10
SCHEMBL11449432 0.74 ALDH1A1 (0.40) FPR1HSD17B10
SCHEMBL11467166 0.71 GAA (0.40) HSD17B10
SCHEMBL2211807 0.63 ERCC1 (0.33)
SCHEMBL11109281 0.62 MAPK1 (0.32)
Benzene SCHEMBL11056466 0.61 GAA (0.48)
SCHEMBL11366516 0.61 GAA (0.42) FPR1HSD17B10
SCHEMBL11105482 0.60 MEN1 (0.31)
SCHEMBL11104823 0.60 MGLL (0.37) HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4395549-A CHEMICAL INTERMEDIATES FOR RUTECARPINE DIURETICS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1983-07-26 US claimed
US-4472399-A Indolo[2',3';3,4]pyrido[2,1-b]quinazoline-5-ones, a process for the preparation thereof, and diuretic compositions and methods using them CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1984-09-18 US disclosed
US-4395549-A CHEMICAL INTERMEDIATES FOR RUTECARPINE DIURETICS CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA RT. (HU) 1983-07-26 US disclosed