Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | CES2 | O00748 | 7/20 | 0.48 |
| ▸ | CES1 | P23141 | 6/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.44 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11052862 | 1.00 | MAPT (0.49) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL1137305 | 0.83 | AKR1C3 (0.59) | MAPTLMNANFKB1CA1CA2 | |
| SCHEMBL208434 | 0.83 | AKR1C3 (0.59) | MAPTLMNANFKB1CA1CA2 | |
| SCHEMBL29833552 | 0.83 | CYP3A4 (0.69) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL4924923 | 0.83 | CYP3A4 (0.69) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL4924930 | 0.83 | CYP3A4 (0.69) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL21198595 | 0.82 | CES2 (0.48) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL21198594 | 0.82 | CES2 (0.48) | MAPTLMNACES2CES1CYP3A4 | |
| SCHEMBL15271482 | 0.81 | MAPT (0.55) | MAPTLMNANFKB1CA1CA2 | |
| SCHEMBL15271480 | 0.81 | MAPT (0.55) | MAPTLMNANFKB1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0025599-B1 | BENZOPYRAN COMPOUNDS, USEFUL AS CHEMOTHERAPEUTIC AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1984-12-19 | — | — | EP | disclosed |
| US-4452991-A | OR BENZO(B)INDENO (2,1-E) PYRANS OR BENZO(C)XANTHENES | BATCHELOR JOHN F (GB) | 1984-06-05 | — | — | US | disclosed |
| EP-0025599-A1 | Benzopyran compounds, useful as chemotherapeutic agents | THE WELLCOME FOUNDATION LIMITED (GB) | 1981-03-25 | — | — | EP | disclosed |