SCHEMBL11053069

SCHEMBL11053069

CCCCNC(=O)N(C(=N)N)c1c(CC)cccc1CC

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.42
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41
ALOX5 P09917 1/20 0.40
KMT2A Q03164 4/20 0.40
MEN1 O00255 3/20 0.40
TDP1 Q9NUW8 1/20 0.40
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
RAB9A P51151 1/20 0.38
HPGD P15428 2/20 0.37
MAPT P10636 2/20 0.36
BCHE P06276 1/20 0.36
ALOX15 P16050 1/20 0.36
KDM4E B2RXH2 1/20 0.36
PABPC1 P11940 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
NAAA Q02083 1/20 0.35
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11056468 0.96 POLB (0.41) POLBSMN1; SMN2HTTALOX5KMT2A
SCHEMBL11056672 0.95 POLB (0.41) POLBSMN1; SMN2TSHRHTTALOX5
SCHEMBL11054316 0.92 TP53 (0.37) POLBKMT2AMEN1TDP1ALDH1A1
SCHEMBL11057291 0.91 HPGD (0.44) POLBSMN1; SMN2TSHRHTTALOX5
SCHEMBL11057738 0.91 TDP1 (0.39) POLBSMN1; SMN2HTTALOX5KMT2A
Hydrochloric Acid SCHEMBL11562345 0.88 ALOX5 (0.42) POLBSMN1; SMN2TSHRHTTALOX5
SCHEMBL11054616 0.88 HPGD (0.40) POLBSMN1; SMN2TSHRHTTKMT2A
SCHEMBL11060091 0.87 ALDH1A1 (0.41) SMN1; SMN2HTTKMT2AMEN1TDP1
SCHEMBL11057149 0.86 CACNA1C (0.38) SMN1; SMN2TSHRHTTKMT2AMEN1
Hydrochloric Acid SCHEMBL11556716 0.84 NAAA (0.40) SMN1; SMN2HTTALOX5KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4452980-A DIARRHEA WILLIAM H. RORER, INC. (US) 1984-06-05 US disclosed
US-4246409-A ANTIDIARRHEAL AGENTS WILLIAM H. RORER, INC. (US) 1981-01-20 US disclosed
US-4225315-A Triazinones from amidinoureas WILLIAM H. RORER, INC. (US) 1980-09-30 US disclosed
US-4147804-A ANTIARRHYTHMIA AGENTS WILLIAM H. RORER, INC. (US) 1979-04-03 US disclosed