Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 6/20 | 0.36 |
| ▸ | RAB9A | P51151 | 6/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11056102 | 0.88 | HTT (0.36) | HTTTBXA2RGAANPC1RAB9A | |
| SCHEMBL11054561 | 0.86 | HTT (0.50) | HTTGAANPC1RAB9APKM | |
| SCHEMBL11057230 | 0.85 | HTT (0.43) | HTTRAB9AMEN1KMT2AMAPK1 | |
| SCHEMBL11053662 | 0.85 | NPC1 (0.49) | HTTNPC1RAB9AMEN1KMT2A | |
| SCHEMBL11052569 | 0.85 | ALDH1A1 (0.43) | HTTTBXA2RNPC1RAB9AMEN1 | |
| SCHEMBL11052904 | 0.84 | HTT (0.47) | HTTMEN1KMT2AMAPK1POLB | |
| SCHEMBL11052091 | 0.84 | NPC1 (0.40) | HTTTBXA2RGAANPC1RAB9A | |
| SCHEMBL11250897 | 0.84 | PKM (0.48) | HTTTBXA2RNPC1RAB9APKM | |
| SCHEMBL11053888 | 0.83 | HTT (0.47) | HTTNPC1RAB9APKMMEN1 | |
| SCHEMBL11050805 | 0.83 | IDH2 (0.39) | HTTTBXA2RNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4488993-A | Amidinoureas | WILLIAM H. RORER, INC. | 1984-12-18 | — | — | US | disclosed |
| US-4220658-A | Treatment of hypertension with amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-02 | — | — | US | disclosed |
| US-4088785-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1978-05-09 | — | — | US | disclosed |